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ATP-responsive Nanoparticles for Reversal of Immune Evasion in Breast Cancer
HEART Pathway Accelerated Diagnostic Protocol Implementation: Prospective Pre-Post Interrupted Time Series Design and Methods.
Leveraging Novel Informatics Tools to Identify and Monitor Pediatric Patients at Risk for Unmet Social Needs
Predictive performance of early warning scores in acute leukemia patients receiving induction chemotherapy.
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Hollis, Thomas
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Hollis, Thomas
Item Type
Name
Academic Article
The TREX1 exonuclease R114H mutation in Aicardi-Goutières syndrome and lupus reveals dimeric structure requirements for DNA degradation activity.
Academic Article
The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering.
Academic Article
The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease.
Academic Article
RNaseH2 mutants that cause Aicardi-Goutieres syndrome are active nucleases.
Academic Article
The structure of the mammalian RNase H2 complex provides insight into RNA.NA hybrid processing to prevent immune dysfunction.
Concept
Protein Structure, Quaternary
Academic Article
The Arg-62 residues of the TREX1 exonuclease act across the dimer interface contributing to catalysis in the opposing protomers.
Search Criteria
Protein Structure Quaternary